EVENTO RESIDENZIALE ECM

MMBRIDGE

Bridging Science and Care in Multiple Myeloma Current Practice and Emerging Advances
12 - 13 Marzo 2026 - Milano

Sede dell'evento:
Hotel Duo Milan
Via Gerolamo Cardano 1 Milano 

Scientific Rationale

The treatment of Multiple Myeloma has undergone significant changes in recent years thanks to advancements in understanding the disease and the increasing availability of new therapeutic agents.
A better understanding of the biology of Multiple Myeloma has made it possible to more accurately identify patients with aggressive disease who require treatment, as well as to stratify the likelihood of response to therapy and long-term survival. New diagnostic approaches, including flow cytometry, radiological, and molecular techniques, now allow the identification of high-risk factors and the measurement of minimal residual disease (MRD) with a sensitivity that was unimaginable just a few years ago.
Advances in therapy have provided clinicians with a vast arsenal of treatment options: the field has shifted from standardized therapy for all patients based on transplant eligibility to the availability of multiple drugcombinations for each line of therapy, requiring increasingly personalized choices. MRD is a new primary endpoint in clinical trials, and in daily clinical practice it will enable targeted personalized therapeutic decisions.
This conference will bring together national and international experts to provide a comprehensive and cross-disciplinary overview of the current state of knowledge on Multiple Myeloma, from its biological foundationsto the latest diagnostic and therapeutic innovations.
Only through a deep understanding by healthcare and research professionals of the changes in the field of Multiple Myeloma will it be possible for patients to fully benefit from the progress achieved so far and from those yet to come.



SCIENTIFIC DIRECTORS

Niccolò Bolli, Milano | Matteo Claudio Da Vià, Milano 
FACULTY
Angelo Belotti (Brescia)
Luca Bertamini (Rotterdam, NL)
Niccolò Bolli (Milano)
Eileen Boyle (London, UK)
Stefania Bramanti (Milano)
Sara Bringhen (Cuneo)
Gabriele Buda (Pisa)
Michele Cea (Genova)
Simone Cenci (Milano)
Paolo Corradini (Milano)
Tom Cupedo (Rotterdam, NL)
Matteo Claudio Da Vià (Milano)
Mattia D’Agostino (Torino)
Daniele Derudas (Cagliari)
Hermann Einsele (Würzburg, DE)
Mirko Friedrich (Heidelberg, DE)
Monica Galli (Bergamo)
Francesca Gay (Torino)
Massimo Gentile (Cosenza)
Annamaria Gullà (Candiolo)
Michael Hudecek (Würzburg, DE)
Martin Kaiser (London, UK)
Jan Krönke (Greifswald, DE)
Carmine Liberatore (Pescara)
Silvia Mangiacavalli (Pavia)


Massimo Martino (Reggio Calabria)
María-Victoria Mateos (Salamanca, ES)
Rita Mazza (Milano)
Vittorio Montefusco (Milano)
Pellegrino Musto (Bari)
Enrique Ocio (Santander, ES)
Bruno Paiva (Pamplona, PT)
Francesco Passamonti (Milano)
Francesca Patriarca (Udine)
Mario Perro (Losanna, CH)
Maria Teresa Petrucci (Roma)
Loredana Pettine (Milano)
Marc Raab (Heidelberg, DE)
Leo Rasche (Würzburg, DE)
Roberto Ria (Bari)
Salomon Manier (Lille, FR)
Alessandra Romano (Catania)
Fredrik Schjesvold (Oslo, NO)
Antonio Giovanni Solimando (Bari)
Carolina Terragna (Bologna)
Cyrille Touzeau (Nantes, FR)
Niels Weinhold (Heidelberg, DE)
Katja Weisel (Hamburg, DE)
Elena Zamagni (Bologna)
Renato Zambello (Padova)

PRELIMINARY PROGRAM

GIOVEDÌ 12 MARZO 2026
13:00 Welcome Lunch
14:00 Registration and welcome

SESSION 1 - THE TUMOR MICROENVIRONMENT AND PRE-CLINICAL
DEVELOPMENT OF MYELOMA
Alessandra Romano, Antonio Solimando

14:30 Genomic determinants of aggressiveness of precursor conditions
Niccolò Bolli
14:42 The pathogenic role of immune tumor microenvironment in the development of Multiple Myeloma
Tom Cupedo
14:54 Clinical implications of microenvironment perturbations in clonal hematopoietic conditions
Matteo Claudio Da Vià
15:06 Discussion

SESSION 2 - HOW AND WHEN WE TREAT MYELOMA?
Michele Cea, Carmine Liberatore

15:30 Curative vs delaying approach to the treatment of smoldering Myeloma
María-Victoria Mateos
15:42 To treat myeloma, we exploit the vulnerabilities of normal plasma cells
Simone Cenci
15:54 To treat myeloma, we target the aberrant pathways of a clonal plasma cell
Jan Kronke
16:06 Discussion
16:25 Coffee Break

SESSION 3 - WHAT ARE THE CURRENT PROGNOSTIC FEATURES IN
MULTIPLE MYELOMA?
Daniele Derudas, Roberto Ria

16:45 Circulating plasma cells: how should we measure them and how many are too much?
Luca Bertamini
16:57 Genetic prognostic and predictive factors in NDMM
Mattia D’Agostino
17:09 Will transcriptomics ever find its place in Myeloma prognostication?
Martin Kaiser
17:21 Discussion

SESSION 4 - FIRST-LINE TREATMENT OF MULTIPLE MYELOMA AND
BIOLOGICAL DETERMINANTS OF RESPONSE
Vittorio Montefusco, Loredana Pettine
17:45 Immunogenic cell death: predictive markers and modifiers
Annamaria Gullà
17:57 Intrinsic and extrinsic mechanisms of resistance to daratumumab And IMiDs
Eileen Boyle
18:09 Current and future maintenance strategies: for who, for how long?
Elena Zamagni
18:21 Quadruplets in NTEMM: for the many or for the few?
Salomon Manier
18:33 Discussion

19:00 END OF DAY 1

VENERDÌ 13 MARZO 2026

SESSION 5 - POST-INDUCTION RESPONSE ASSESSMENT AND NOVEL
STRATEGIES OF CLINICAL MANAGEMENT
Ciro Botta, Renato Zambello

09:00 NGS for risk assessment at diagnosis and MRD measurement
Carolina Terragna
09:12 Bone marrow and Peripheral Blood Residual Disease by NGF and other methods
Bruno Paiva
09:24 MRI and PET-CT to evaluate treatment response.
Angelo Belotti
09:36 What is new in treatment algorithms of TE patients?
Francesca Gay
09:48 Discussion

SESSION 6 - HOW DO WE APPROACH RELAPSED MYELOMA WITHOUT
T-CELL REDIRECTING THERAPIES TODAY? 
Monica Galli, Maria Teresa Petrucci

10:15 Anti-CD38 treatments in relapsed-refractory myeloma
Enrique Ocio
10:27 Anti-BCMA ADC combinations at first relapse
Sara Bringhen
10:39 Novel small molecules in the treatment of myeloma
Gabriele Buda
10:51 Indications and efficacy of Celmods
Fredrik Schjesvold
11:03 Discussion
11:25 Coffee Break

SESSION 7 - T-CELL REDIRECTING THERAPIES FOR REFRACTORY MYELOMA

Paolo Corradini, Francesco Passamonti

11:45 Latest updates on CAR-T treatment
Hermann Einsele
11:57 Bispecific antibodies in relapsed-refractory myeloma
Cyrille Touzeau
12:09 Resistance to anti-BCMA and anti-GPRC5D
Niels Weinhold
12:21 How to manipulate/rest the microenvironment for improving T-cell redirection
Leo Rasche
12:33 Discussion
13:00 Lunch

SESSION 8 - PATIENT SELECTION AND STRATEGIES TO MAXIMIZE EFFICACY OF T-CELL BASED IMMUNOTHERAPIES
Massimo Gentile, Francesca Patriarca

14:30 Why treat a patient with CAR-T? A case report
Rita Mazza
14:40 Why treat a patient with a T-cell engager? A case report
Silvia Mangiacavalli
14:50 Immunological bases for efficacy of T-cell redirecting therapies, or
lack thereof
Mirco Friedrich
15:05 The Future of Immunotherapy in MM
Marc Raab
15:20 Discussion

SESSION 9 - FUTURE APPROACHES IN THE TREATMENT OF MYELOMA

Massimo Martino, Pellegrino Musto

15:45 Trispecific antibodies in RRMM
Mario Perro
15:57 Ad-hoc trials for high-risk patients
Katja Weisel
16:09 What will it take to implement outpatient management of CAR-T/TCE patients?
Stefania Bramanti
16:23 Future CAR-T approaches in myeloma
Michael Hudecek
16:45 Discussion
17:10 CLOSING REMARKS AND ADJOURN
Niccolò Bolli, Matteo Claudio Da Vià

ECM e Destinatari del corso

ECM - n. 740 – 471759 Edizione n° 1

All’evento sono stati assegnati 9 crediti ECM

Destinatari dell’iniziativa:
MEDICO CHIRURGO con specializzazione in: EMATOLOGIA; GENETICA
MEDICA; MEDICINA INTERNA; ONCOLOGIA; ANATOMIA PATOLOGICA;
BIOCHIMICA CLINICA; LABORATORIO DI GENETICA MEDICA; PATOLOGIA
CLINICA (LABORATORIO DI ANALISI CHIMICO-CLINICHE E MICROBIOLOGIA);
Obiettivo formativo: 3 – Documentazione clinica. Percorsi clinicoassistenziali
diagnostici e riabilitativi, profili di assistenza - profili di cura.

Logistica e modalità di partecipazione:

La partecipazione al convegno è gratuita e subordinata a iscrizione obbligatoria, fino a esaurimento dei posti disponibili. Le spese di viaggio e di ospitalità sono a carico del Discente. 

La partecipazione al convegno include l’accesso ai lavori congressuali, il lunch previsto per il giorno 12 marzo e i due coffee break previsti da programma.

Con il patrocinio di:

AIRC - Associazione Italiana per la Ricerca sul Cancro
Fondazione IRCCS Ca’ Granda — Ospedale Maggiore Policlinico
GITMO — Gruppo Italiano per il Trapianto di Midollo Osseo, cellule staminali emopoietiche e terapia cellulare
SIE — Società Italiana Ematologia
SIES — Società Italiana Ematologia Sperimentale
Università degli Studi di Milano